Journal article
The association of HPV-16 seropositivity and natural immunity to reinfection: Insights from compartmental models
IA Korostil, SM Garland, MG Law, DG Regan
BMC Infectious Diseases | BMC | Published : 2013
Abstract
Background: Seroreactivity, processes of seroconversion and seroreversion, in the context of HPV infection has been investigated in numerous studies. However, the data resulting from these studies are usually not accounted for in mathematical transmission models of various HPV types due to gaps in our understanding of the nature of seroreactivity and its implications for HPV natural history. Methods: In this study we selected a number of simple but plausible compartmental transmission models of HPV-16, differing in assumptions regarding the relation between seropositivity and immunity, and attempted to calibrate them to Australian HPV seroprevalence data for females and males, as well as DNA..
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Awarded by GlaxoSmithKline
Funding Acknowledgements
The authors of this manuscript do not perceive any direct conflict of interest in relation to the research described. However, in the interest of full disclosure, we declare the following: The research described in this manuscript was funded by an Australian Research Council Linkage Project (LP0883831). CSL Limited, the distributor of Gardasil (R) in Australia and New Zealand, is a Partner Organization on this project. Igor Korostil's salary is funded by the above mentioned grant (LP0883831). Professor Suzanne Garland has received advisory board fees and grant support from CSL Ltd and GlaxoSmithKline (GSK), and lecture fees from Merck, GSK and Sanofi Pasteur; in addition, she has received funding through her institution to conduct HPV vaccine studies for Merck and GSK. She is a member of the Merck Global Advisory Board as well as the Merck Scientific Advisory Committee for HPV. This work was supported by an Australian Research Council Linkage Project [LP0883831] and a National Health and Medical Research Council Program Grant [568971]. The Kirby Institute receives funding from the Australian Government Department of Health and Ageing. The views expressed in this publication do not necessarily represent the position of the Australian Government. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales.